The Associated Press
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Wilson threw TDs to Lynch, Anthony McCoy and two in the second half to Doug Baldwin to give him 25 for the season, one shy of Peyton Manning's record of 26. Lynch added 111 yards rushing and a 24-yard TD run on Seattle's opening drive that set the tone.
Richard Sherman returned a block field goal 90 yards for a touchdown and added an interception for the Seahawks (10-5).
Colin Kaepernick and the 49ers (10-4-1) struggled with the deafening noise echoing around CenturyLink Field, making for a miserable 49th birthday for 49ers coach Jim Harbaugh.